Bartonella and Lyme Symptoms

Posted July 11, 2012  Another interesting article on Bartonella.  Often times the lyme symptoms aren’t just cause by the Borrelia burgdorferi there can be co-infections such as Bartonella.  Good article

bartonella and lyme symptoms

Bartonella is a common co-infection and can mimic lyme symptoms

 

Bartonella: A New Frontier in Chronic Disease

Written by  on July 2, 2012 in

New molecular test leads to surprising new research implicating Bartonella in rheumatological illness

By Edward B. Breitschwerdt DVM, CEO/CSO Galaxy Diagnostics & B. Robert Mozay

New research recently published in the journal of Emerging Infectious Disease supports an association between Bartonella infection and rheumatological symptoms. The researchers tested 296 immunocompetent patients for evidence of Bartonella infection. Bacteremia with one or more Bartonella species was found in (41 percent) of patients with a prior diagnosis of Lyme disease (47 percent), arthralgia/arthritis (21 percent), chronic fatigue (20 percent) and fibromyalgia (6 percent). This study follows two decades of medical case series research implicating Bartonella infection in chronic diseases affecting the joints, neurological and vascular systems.

Bartonella are highly fastidious, immune-evasive, gram-negative bacteria which infect at very low levels of detection. As a result, conventional serological and polymerase chain reaction (PCR) testing technologies are of limited value for the confirmation of infection. These surprising new findings were made possible by a new testing technology developed by researchers at the North Carolina State University College of Veterinary Medicine(NCSU-CVM). The NCSU research team discovered a way to overcome past testing challenges through the development and use of a propriety enrichment media (Bartonella alpha-proteobacteria growth medium or BAP-G-M). When paired with highly sensitive PCR testing, the BAPGM media increases the sensitivity of detection by 4 to 5 times over conventional methods.

Popularly known as the key agents in cat scratch disease (CSD), trench fever, and carrion’s disease, Bartonella were essentially rediscovered in the 1990s with the emergence of HIV and the clinical application of DNA testing technologies. There are now over 25 characterized species of Bartonella, 12 of which have been documented as pathogenic for humans. A wide range of animals serve as natural hosts for this zoonotic bacteria, most significantly the cat and rodent populations, which may be transmitted by a number of different vectors including fleas, lice, ticks, and biting flies.

A 2004 Nature article describes Bartonella as one of the most important pathogens in emerging infectious disease along with Helicobacter pylori (H. pylori). Unlike H. pylori, however, Bartonella is not localized to the gastrointestinal (GI) tract, but can infect multiple systems in the body.

Well-established as life-threatening in patients with compromised immune systems, the emerging research indicates that Bartonella are also a problem in patients with competent immune systems. Research on HIV patients, suggests a pattern of progressive presentations of bartonellosis from mild CSD symptoms to peliosis hepatitis and bacillary angiomatosis. Bartonella has also been documented as a cause of culture-negative endocarditis, osteomyelitis, meningitis, encephalitis, neuroentinitis and vasculitis.

Mounting case evidence indicates that atypical presentations of cat scratch disease may not be nearly as uncommon as previously thought, especially in high-risk patient populations. Symptoms may range from recurring fever, headaches, insomnia, joint/muscle aches and pains to arthropathy, myalgia, neurocognitive and neuromotor dysfunction, seizures, vasculitis, and vaso-proliferative tumors or lesions, as well as the more common lymphadenopathy and splenomegaly.

Risk factors associated with Bartonella infection include high levels of animal contact and vector exposure. In an earlier study using the Bartonella ePCR™ test, the NCSU research team found that 23.9 percent of 192 patients with occupational animal contact or extensive arthropod exposure were bacteremic with one or more Bartonellaspecies when blood, serum and BAPGM enrichment culture PCR results were combined. Although this high prevalence of bacteremia is biased by testing at-risk, sick individuals, it clearly demonstrates that intravascular infection with Bartonella species is much more common in immunocompetent patients than was previously suspected.

Importantly, Bartonella infection may also represent a safety concern in the blood supply in transplant medicine and chronic disease management. Of particular concern are medical conditions managed with therapeutic regimens that cause immune suppression, including rheumatologic diseases such as rheumatoid arthritis or lupus, or organ transplantation. Other conditions, such as cancer, may involve the use of medications that cause immune suppression, such as high-dose steroid components of lymphoma protocols. Blood banking practice must also consider the potential for the transmission of Bartonella through transfusion of blood products.  These safety issues indicate the need for better prevalence studies to determine the cost-benefit of screening for safety reasons, including the screening of blood products.

Recommendations for medical practitioners:

  • Consider testing patients at high risk who present with general rheumatic or neurological symptoms for Bartonella infection.
  • Make clinical protocols involving immune suppression, including transplantation and cancer treatments, safer by testing high-risk patients for Bartonella infection.
  • Advise patients to exercise routine precautions to avoid animal bites and scratches when dealing with domestic or wild animals and to avoid exposure to arthropod and insect vectors.

The emerging research on Bartonella is very compelling and the need for clinical research that directly addresses the role these bacteria play in human and animal health is clear. Because the genus Bartonella involves multiple animal reservoirs, animal and human disease, arthropod and insect vector transmission, and an environmental impact on human health, multidisciplinary research efforts following the One Health Initiative are needed to effectively address the far-reaching implications and the redefinition of “bartonellosis” as an emerging infectious disease of the 21st century.

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Meditation, Exercise and Lyme Symptoms

Running lyme symptoms

Ready to Run! No More Lyme or Lyme Symptoms!

Posted July 11, 2012.  I did a lot of visualization when I was bedridden with Lyme and Lyme symptoms.  I would see myself well: running, dancing, walking normally.  Tonight I ran the Santa Barbara Night Moves 5K race again, as I do every Wednesday night during the summer.  My time continues to get better!  There was just posted an interesting article in Medscape News:  Training in mindfulness meditation and sustained moderate-intensity exercise appear to be associated with reduced illness severity and fewer days of missed work because of acute respiratory infections (ARIs), compared with doing nothing, according to the findings of a randomized trial.  Meditation and exercise sure helped me climb out of the Lyme and Lyme symptoms pit!   Hope they can help you too!  Good study.

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Lyme Symptoms: Gluten?

Lyme Symptoms: Gluten?

Posted July 10, 2012.  Here’s a good article about gluten.  I don’t do gluten any more.  I think gluten exacerbates lyme symptoms and symptoms of other illnesses.  Something to think about.  

Going Gluten-free by David E Koronet DC 2012

 

One in 133 people in the US are allergic to gluten according to the latest estimates. Most supermarkets have gluten-free sections. You hear people talking about giving up gluten and maybe you are thinking of doing so yourself. How do you do this – and should you?

 

What is gluten? Gluten is a protein found in three grains: wheat, barley, and rye. There sometimes can be cross contamination of oats if they grow next to a wheat field as well.

 

What is a gluten allergy? An allergy to gluten is called celiac disease. Any contact with gluten protein leads to an immune reaction in someone with celiac disease. Avoiding gluten is tougher than it seems: many processed foods contain wheat or barley (as flour, for example), and someone with celiac disease shouldn’t eat gluten-free bread toasted in a toaster which is used for regular bread – they will react to it. Generally, stomach upset is the most common symptom, but a host of neurologic symptoms have also been found in reaction to the protein.

 

What is gluten sensitivity? Some people are not allergic to gluten, but they get some immune response to gluten. It is not as severe as a reaction in someone with celiac disease, but may show up as a bloated feeling, or gassiness. sensitivity is believed to be more common than a gluten allergy. There are a number of researchers who have found a link between fighting a chronic disease and the development of gluten sensitivity (this occurs through a change in the intestinal lining; it is believed to that an immune reaction to the protein develops – and to dairy proteins as well). The extreme measures someone with celiac disease aren’t necessary, but wheat, barley, and rye should still be avoided.

 

How do I know if I should avoid gluten? If you have celiac disease, there are blood tests which can confirm it (IgA and IgG anti-gliadin antibodies;  tTG [anti-tissue transglutaminase]-IgA; and EMA [anti-endomysial antibodies]). If you are gluten sensitive, those tests won’t be positive. Instead, I recommend an elimination diet: staying off gluten for at least two weeks and seeing if you feel better, then re-introducing gluten and see if anything changes. You’ll want to go heavy on the gluten when you re-introduce it – you’ll know within a few days if you are reacting to it.

 

So, I’m not supposed to have gluten – what should I look out for, and what can I eat? As I noted before, you need to avoid wheat, barley and rye. At its most basic, this means no bread, no pasta, no crackers or pretzels, no baked goods (muffins, pastries, cookies…) unless they specifically say they are gluten-free. Anything which contains spelt, bulgur, faro, semolina, or farina is out (they are forms of wheat), as is anything containing triticale (a cross between wheat and rye). There are more subtle places that gluten turns up: beer (brewed from barley), many soups (they use flour to thicken them; some may also contain pearled barley), soy sauce (first ingredient is usually wheat), sausage (often uses wheat as a filler), anything that contains “malt” (it’s from malted barley), ketchup and salad dressings, even ice cream (as an add-in – think chocolate chip cookie dough – or as a thickener). What’s more, vegetable protein (hydrolyzed or not), modified food starch, and dextrin and maltodextrin can come from wheat, and “natural and artificial flavors” may come from barley. If you get the idea that you are going to need to read labels carefully, you are absolutely right. Luckily, many gluten-free foods are labeled as such.

 

What can you eat? Any meats, poultry, or fish (with the note about watching for sausage and hot dog fillers), any eggs or dairy (though some who are sensitive to gluten may be sensitive to dairy proteins too), and fruits or vegetables. There are quite a few grains which don’t contain gluten: rice, corn, millet, quinoa, amaranth, and buckwheat (which is not related to wheat) are all fair game. Oatmeal is okay if it is specifically labeled as gluten-free. Most gluten-free substitutes contain one or more of these: there are gluten-free breads (Rudi’s and Udi’s are two brands of this), pastas (usually rice, corn, or quinoa based – and oriental rice noodles are a good substitute for regular pasta – but check the ingredient list to make sure there’s no wheat mixed in), pretzels, even gluten-free beer. A couple of companies make gluten-free soy sauce – and if you are eating out (at a Japanese steak house, for example), you can request them. There are baking mixes which are gluten-free – or you can use a gluten-free flour mix or rice flour, possibly combined with corn or potato starch when you bake.

 

What about dropping all grains? It has become popular in some circles to say all grains are unhealthy and avoid them. The evidence I have seen of this hasn’t convinced me yet. I think the issue with most grains is that they are refined – basically, all of the healthy parts of them removed (white rice, white flour…) – and that is a risk with cutting gluten out of your diet: most people rely especially on wheat for the whole grains they get in their diet. Minimize the processed versions of gluten-free grains – use whole corn instead of corn starch when you can, add some cooked millet or quinoa if you are baking gluten-free bread, use millet as a substitute for couscous (which is wheat).

 

What else will I need to do? If you have celiac disease, you will need to get some new kitchen equipment which is to be kept gluten-free: cutting boards, silicon or wooden cooking utensils (metal doesn’t have to be replaced), non-stick or iron pans, rolling pins, muffin tins and baking sheets, plastic bowls, colanders, and yes, a toaster. If you are gluten sensitive, you may not need to do this – though it certainly doesn’t hurt to do so.

 

How hard is it to do this? At first, it isn’t too easy – for most of us, bread, pasta, and baked goods are dietary staples, and we aren’t used to reading labels. On the other hand, my older daughter went gluten- and dairy-free last February at age 16 as part of her fight with Lyme disease, and has managed to stick with it, even when the rest of the family was not restricting themselves. I went off gluten and dairy myself for several months earlier this year (didn’t have a dramatic effect, so now I’m back on gluten). In time, you learn to read labels and cook and bake gluten-free – it gets easier as time goes by. Many restaurants now have gluten-free menus, which lets you know what you can or shouldn’t order. It can be inconvenient to go gluten-free at times – but not impossible.

 

David E Koronet DC 2012

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Lyme Symptoms: Vitamin D

Posted July 7, 2012  I still take vitamin D for my immune system, here’s an interesting article.  Good for Lyme, good for the bones!! From Medscape News:  Those older than 65 years who take high doses of vitamin D lower their risk of suffering a fracture from 14% to 30%, according to a pooled analysis that demonstrated fracture risk reduction only at the highest level of vitamin D intake.

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Lyme Test Negative? It May Still Be Lyme Disease!

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